Creating human locus coeruleus organoids to study the role of the locus coeruleus in Alzheimer’s disease
LC organoids are distinct from cortical organoids and contain many markers of human LC neurons. Studying the structure and function of LC organoids derived from both healthy controls and AD patients may provide new insights into the role of the LC in AD.
Authors
- Fikri Birey (ORCID: https://orcid.org/0000-0003-2632-2764)
- Margaret M. Tish (ORCID: https://orcid.org/0000-0002-8954-1983)
- Zhishuo Ou
- David Weinshenker (ORCID: https://orcid.org/0000-0002-3678-6215)
Institutions
- Emory University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089378
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00