Analysing the Genetic Mosaic of Relapsing Remitting vs Clinically isolated syndrome Multiple Sclerosis: A Bioinformatics Perspective on Subtype‐Specific Variations
In RRMS, TRIM36's role in proteostasis and neurodegeneration is highlighted, with protein-protein interaction analysis showing dysfunctional ubiquitination. Altered antigen processing and presentation in CIS compared to healthy individuals and RRMS suggest differences in pathophysiology in this subtype. Furthermore, recent study has suggested CYBRD1 as a potential MS biomarker.
Authors
- Vishwajit Ravavindra Deshmukh (ORCID: https://orcid.org/0000-0002-6970-6699)
- S. C. Tripathi (ORCID: https://orcid.org/0000-0003-3917-9645)
- Snehal Chandak
- Mahesh P. Suryawanshi (ORCID: https://orcid.org/0000-0003-4711-7655)
- Ashlesh Patil (ORCID: https://orcid.org/0000-0001-5942-8173)
- Aman Bhonsale (ORCID: https://orcid.org/0000-0002-6518-5785)
- Parag M. Phadke
- Sarthak Pakhmode
- Ishita Varma
- Atharva Subhedar
- Shreya Khankar
- Siddhali Mast
- Tapesh Lalotra
Institutions
- All India Institute of Medical Sciences Raipur (IN)
- All India Institute of Medical Sciences, Nagpur (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093046
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00