Chronic traumatic encephalopathy neuropathologic change is associated with higher stage limbic‐predominant age‐related TDP‐43 encephalopathy
These results demonstrate rmTBI is associated with higher stage LATE pathology than in equivalent age matched controls and individuals with wider, non-TBI related NDD. Further studies are required to characterize the association between TBI and TDP-43 proteinopathy, including the contribution, if any, of this pathology to clinical sequelae of TBI related neurodegenerative disease.
Authors
- Jean-Pierre Dollé (ORCID: https://orcid.org/0000-0002-4829-0268)
- William Stewart (ORCID: https://orcid.org/0000-0003-2199-2582)
- Douglas H. Smith (ORCID: https://orcid.org/0000-0002-0813-421X)
- Eddie B Lee
- Claire Kennedy‐Dietrich
- Kamar E. Ameen‐Ali (ORCID: https://orcid.org/0000-0002-7583-4099)
- Hailong Song
Institutions
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
- University of Pennsylvania (US)
- Teesside University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084996
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00