Variant‐gene pair in <i>silico</i> analyses and functional validation of LOAD GWAS loci in human brain‐relevant cell types identify <i>EGFR</i> as a target gene for potential drug repurposing
Together, we identified a novel LOAD-associated neuronal enhancer that drives EGFR gene expression. Further research is needed to investigate if EGFR inhibitors approved as anti-cancer drugs can serve as potential candidates for repurposing as LOAD therapeutics.
Authors
- Weixin Wang (ORCID: https://orcid.org/0000-0002-2765-2629)
- Alessandra Chesi (ORCID: https://orcid.org/0000-0002-0954-7446)
- Pavel P. Kuksa (ORCID: https://orcid.org/0000-0003-2248-6403)
- Shannon Laub (ORCID: https://orcid.org/0000-0002-4917-5042)
- Yuk Yee Leung (ORCID: https://orcid.org/0000-0002-3047-5440)
- Natalia Tulina (ORCID: https://orcid.org/0000-0002-1997-4521)
- Jeffrey Cifello (ORCID: https://orcid.org/0009-0000-6147-2026)
- Emily Greenfest‐Allen (ORCID: https://orcid.org/0000-0002-7294-8461)
- Gerard D. Schellenberg (ORCID: https://orcid.org/0000-0003-1115-2475)
- Louisa Boateng
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087633
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00