Distinct Methylomic Signatures Emerge in the Prefrontal Cortex Following Amyloid‐Beta Immunisation, with Altered Expression Patterns in Astrocytes

Indicating better inflammatory markers can help inform of effective preventative care strategies for elders. This study provides evidence for altered epigenetic processes in the pathophysiology of AD and identifies novel processes specific to Aβ immunotherapy. The next step for this project includes analysing genotyping data to identify potential methylation quantitative trait loci and further our understanding of the relationship between single nucleotide polymorphisms and methylation changes.