Genetic overlap between Alzheimer’s disease and immune‐mediated diseases: An atlas of shared genetic determinants and biological convergence
Our results suggest a genetic relationship between AD and the 11 immune-mediated diseases, pinpointing the existence of a shared however non-causal genetic basis. These identified protein-coding genes have the potential to serve as a novel path to therapeutic interventions for both AD and immune-mediated diseases and their comorbidities.
Authors
- Nitesh Enduru (ORCID: https://orcid.org/0000-0002-0255-706X)
- Zhongming Zhao (ORCID: https://orcid.org/0000-0002-3477-0914)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Shahram Bahrami (ORCID: https://orcid.org/0000-0002-8179-2788)
- Yulin Dai (ORCID: https://orcid.org/0000-0003-1874-7893)
- Brisa S. Fernandes (ORCID: https://orcid.org/0000-0002-3797-7582)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089871
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23