Carbonic Anhydrase Inhibitors rescue microvascular impairment and neuroinflammation in 3xTg AD mice

CAIs show positive behavioral outcomes in 16-month-old 3xTg mice, and reduce brain amyloidosis, compared to untreated animals. In the hippocampus, CAIs foster microvascular health and reduce inflammatory state, and in the cortex, MTZ decreases microgliosis, unveiling cell specific CAI effects underlying Aβ deposition reduction observed in both areas. This work points to CAIs as a potential therapeutic strategy to treat brain microvascular impairment and neuroinflammation, preventing mitochondria-mediated cell stress and death.