Phenotypic characterization of a novel hAb‐KI<sup>loxP</sup>;hAPOE4;Trem2<sup>R47H_NSS</sup> mouse model
hAb induces robust LTP deficits that are prevent by either hAPOE4 or TREM2*R47H, contrary to expectations. However, hAPOE4 and Trem2<sup>R47H NSS</sup> variants have a cumulative detrimental effect on axonal damage when combined with aging.
Authors
- Ángela Gómez-Arboledas (ORCID: https://orcid.org/0000-0001-9636-9512)
- Marcelo A. Wood (ORCID: https://orcid.org/0000-0003-2029-4176)
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Enikö A. Kramár (ORCID: https://orcid.org/0009-0003-2279-7743)
- Yegang Lü (ORCID: https://orcid.org/0000-0003-3845-5038)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Giedre Milinkeviciute (ORCID: https://orcid.org/0000-0003-2527-3892)
- Celia Da Cunha
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Kim N. Green
- Jonathan Neumann
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092579
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00