Microtubule‐Associated Protein Tau (MAPT) in non‐transgenic and transgenic P301S mouse lenses

There was no overt difference in lens phenotype between the P301S transgenic and non-transgenic mice. However, the banding pattern observed by Western blot for P301S transgenic mice compared to non-transgenic was different. Our data suggest the P301S tau mutation affects tau processing but does not result in a cataract phenotype. Based on our current and previous results, the data suggests that Aβ may play a more significant role than tau in lens pathology in AD.