DNA Methylation Drives Gene Networks Dysregulated in Alzheimer’s Disease
Our study is the most extensive genome-wide investigation on the impact of methylation on AD pathology, and the first integrative survey on the complex interactions between methylation, chromatin accessibility, and multiscale transcriptomic and proteomics networks in AD.
Authors
- Erming Wang (ORCID: https://orcid.org/0009-0000-8056-0785)
- Bin Zhang (ORCID: https://orcid.org/0000-0001-9214-1588)
- Vahram H. Haroutunian (ORCID: https://orcid.org/0000-0001-5860-2512)
- Gongqi Yu (ORCID: https://orcid.org/0000-0001-7654-5232)
- Abigail L. Thorpe (ORCID: https://orcid.org/0000-0001-7153-9140)
- Minghui Wang (ORCID: https://orcid.org/0000-0001-9171-4962)
Institutions
- James J. Peters VA Medical Center (US)
- Mental Illness Research, Education and Clinical Centers (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089178
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00