Age and Sex Impact Alzheimer’s Disease‐associated Plaques and Tangles in Down Syndrome
These results suggest age significantly impacts AD pathology in DS, with neuropathologies presenting in the frontal cortex approximately 10 years earlier than the occipital. Trends indicate sex does appear to have an impact on these pathologies, particularly in the occipital cortex where ptau was found to have a stronger association with age in women. Collectively, this warrants further investigation on the impact of sex and age on AD neuropathology in DS and the contributing mechanisms.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- André Ricardo Pereira da Rosa (ORCID: https://orcid.org/0000-0001-5502-1181)
- Freddy Gonzalez
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Elizabeth J. Andrews (ORCID: https://orcid.org/0000-0003-2463-5708)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Jesse R. Pascual (ORCID: https://orcid.org/0000-0002-3307-0887)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Sierra Wright
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Michael Phelan
- Phong Ngo
Institutions
- Brigham and Women's Hospital (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091923
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00