Integrative approach to profile resilience and risk factors in Alzheimer’s disease
Our study uncovers microglia subtype specific resilience and risk factors provided by AD related genetic variants using snRNAseq from frozen human brain and scRNAseq from IPSC derived microglia cells. These findings nominate novel targets and pathways with therapeutic potential.
Authors
- Wang Xue
- Katie D. Sotelo
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Merve Atık
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Frederick Q Tutor‐New
- Özkan İş (ORCID: https://orcid.org/0000-0003-4070-6756)
- Yuhao Min (ORCID: https://orcid.org/0000-0001-8775-8743)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Venkata N.S. Duvuuri
- Thuy Nguyen (ORCID: https://orcid.org/0000-0002-6283-7602)
- Junli Gao (ORCID: https://orcid.org/0000-0002-8207-5545)
- Jeremiah Bergman
Institutions
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091859
- Primary Topic
- Resilience and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00