Impaired mechanisms of context encoding in APP/PS1 mice are rescued by increasing cerebral blood flow
These results highlight the association between place cell stability and subsequent aSWR dynamics as a potential mechanism contributing to an impaired cognitive map in AD. Importantly, the rescue of behavioral features and aSWR physiological properties following anti-Ly6G antibody treatment suggests that increasing CBF may be a candidate therapy to mitigate spatial memory impairments in AD.
Authors
- Azahara Oliva (ORCID: https://orcid.org/0000-0003-1206-7125)
- Julien Letendre
- Ralitsa Todorova (ORCID: https://orcid.org/0000-0003-2238-0297)
- Laura E. Berkowitz (ORCID: https://orcid.org/0000-0002-4285-2995)
- Nozomi Nishimura (ORCID: https://orcid.org/0000-0003-4342-9416)
- Antonio Fernández‐Ruiz (ORCID: https://orcid.org/0000-0001-8481-0796)
- Chris B. Schaffer (ORCID: https://orcid.org/0000-0002-7800-9596)
- Xin Dong
- Junichiro SHIMIZU
- Dana I Cabus
- Natalie Tehrani
Institutions
- Cornell University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088988
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00