Chronic heavy alcohol intake and liver‐specific LRP‐1 reduction increase amyloidosis in Alzheimer’s disease mice
Chronic heavy alcohol intake reduced hepatic LRP-1 expression, and hepato-specific LRP-1 silencing increased brain Aβ and spatial memory deficits in APP/PS1 mice. Our results place hepatic LRP-1 as a potential key driver of brain amyloidosis in alcohol-dependent AD.
Authors
- Adenike Oyegbesan
- Urvashi Panchal (ORCID: https://orcid.org/0000-0002-3182-6150)
- Devaraj V. Chandrashekar
- Ross A. Steinberg (ORCID: https://orcid.org/0000-0002-3530-2557)
- Nataraj Jagadeesan (ORCID: https://orcid.org/0000-0002-2804-6145)
- Shripad S. Bhagwat
- Joshua Yang (ORCID: https://orcid.org/0000-0003-2410-7817)
- Rachita K. Sumbria (ORCID: https://orcid.org/0000-0002-7459-0723)
- Moom R. Roosan (ORCID: https://orcid.org/0000-0002-5318-5120)
- G. Chuli Roules
- Derick Han (ORCID: https://orcid.org/0000-0001-7550-0438)
- Hiya Rakholia
- Rutvi D. Mevawala
- Trinh Roselyn
Institutions
- Chapman University (US)
- Keck Graduate Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087662
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00