Spermidine Treatment Attenuates Systemic and Gut Oxidative Stress, Neuropathology and Cognitive Deficits in D‐galactose Induced Aging Rats
Our findings suggest that spermidine exerts the beneficial effects on cognition through reducing systemic/brain oxidative stress in D-galactose-induced aging rats. Therefore, it is possible that spermidine should be considered as a novel therapeutic option for ameliorating neuropathology in aging condition.
Authors
- Wichida Kaorop
- Napapan Kangwan (ORCID: https://orcid.org/0000-0002-9184-7850)
- Wasana Pratchayasakul (ORCID: https://orcid.org/0000-0003-3970-4323)
- Busarin Arunsak (ORCID: https://orcid.org/0000-0002-5120-288X)
- Aphisek Kongkaew (ORCID: https://orcid.org/0000-0003-0671-9481)
- Napatsorn Saiyasit
- Chanon Kunasol (ORCID: https://orcid.org/0000-0003-1744-0005)
- Siriporn C. Chattipakorn (ORCID: https://orcid.org/0000-0003-1677-7052)
- Nipon Chattipakorn
- Chayadom Maneechote
- Nattapat Ngowthammatas
- Suriphan Donchada
Institutions
- University of Phayao (TH)
- Chiang Mai University (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086335
- Citations
- 1
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.27