Systemic thymulin overexpression mitigates cognitive and molecular impairments in a rat model of sporadic Alzheimer’s Disease
We explored a minimally invasive therapeutic strategy that allowed us to fully or partially reverse behavioural and molecular changes in our animals with sAD. Therefore, our results are encouraging and suggest that thymulin administration may be a promising therapeutic approach, warranting consideration in sAD studies.
Authors
- Joaquín Pardo (ORCID: https://orcid.org/0000-0002-4028-7339)
- Paula C. Reggiani (ORCID: https://orcid.org/0000-0003-3784-3864)
- Juliette López Hanotte (ORCID: https://orcid.org/0000-0001-8975-8050)
- Facundo Peralta (ORCID: https://orcid.org/0009-0004-8470-460X)
- Ana Abril Vidal Escobedo
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089851
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00