Altered neutrophil glycolysis contributes to microvascular inflammation in an AD mouse model

This data demonstrates that reactive neutrophils in AD mice contribute to capillary stalling and CBF reductions. Glucose metabolism is reduced in neutrophils, indicating a metabolic shift from aerobic to anaerobic glycolysis. Overall, the data shows that neutrophils are more reactive at baseline in AD mice and likely contribute directly to chronic inflammation seen in mouse models and patients with AD.