C‐reactive protein as an inflammatory biomarker for early Alzheimer’s Disease pathogenesis

In conclusion, the results from this study indicate an association between decreasing CRP levels and the progression of early AD pathogenesis. Though elevations in CRP may be a negative prognostic marker in other diseases, associated with brain aging and inflammation, the immune system might be altered depending on the stage of the disease with CRP levels elevated decades before disease onset, decreased years before and during the early stages of the disease, then finally increased again in more advanced stages of the disease. No relationship was found between CRP level and MMSE score.