Elevated brain miR298 is associated with a reduced risk of Alzheimer’s disease
These studies suggest that miR298 regulates a coordinated network of AD-related proteins APP, BACE1, and tau. Hence, such network regulation may represent a rational therapeutic target for reducing AD risk and disease modification. In addition to late-onset cases, we will profile miR298 in brain tissue samples from early-onset AD cases. Future work involves testing miR298 in AD animal models, such as in human tau-overexpressing transgenic mice. We sincerely thank grant support from NIA/NIH.
Authors
- Bryan Maloney (ORCID: https://orcid.org/0000-0003-2364-9649)
- Kumar Sambamurti (ORCID: https://orcid.org/0000-0001-9507-9214)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Bernardino Ghetti (ORCID: https://orcid.org/0000-0002-1842-8019)
- Nigel H. Greig (ORCID: https://orcid.org/0000-0002-3032-1468)
- Scott Counts (ORCID: https://orcid.org/0000-0003-2851-9763)
- Fletcher A. White (ORCID: https://orcid.org/0000-0002-8408-9262)
- Debomoy K. Lahiri (ORCID: https://orcid.org/0000-0002-1664-5933)
- Ruizhi Wang (ORCID: https://orcid.org/0009-0008-8215-3524)
- Subodh Kumar (ORCID: https://orcid.org/0000-0003-0553-387X)
Institutions
- Texas Tech University (US)
- Medical University of South Carolina (US)
- National Institute on Aging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Michigan State University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089848
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00