Clinical Phenotypes of Alzheimer’s Disease: Atrophy Patterns and their Pathological Correlates
Atrophy patterns between AD phenotypes showed only minor differences, potentially attributable to the on average later disease stage of the study cohort. The higher immunoreactivity for pathological markers found in atypical AD might suggest a more severe disease burden. (Para) hippocampal volume decline was associated with axonal and microvascular deterioration in typical AD, but not in the higher pathologically burdened atypical AD group, suggesting a differential susceptibility between AD phenotypes.
Authors
- Irene Frigerio (ORCID: https://orcid.org/0000-0003-1780-2862)
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Laura E. Jonkman (ORCID: https://orcid.org/0000-0003-1479-3649)
- Jeroen J.M. Hoozemans (ORCID: https://orcid.org/0000-0002-2888-8967)
- Elizabeth Gordón (ORCID: https://orcid.org/0000-0001-5935-2463)
- Niels Reijner
- Femke H. Bouwman (ORCID: https://orcid.org/0000-0002-0527-2270)
- Thomas Jubault
- Baayla D.C. Boon (ORCID: https://orcid.org/0000-0002-4922-3286)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Wilma D. J. van de Berg (ORCID: https://orcid.org/0000-0002-6175-5357)
- Nicolas Guizard (ORCID: https://orcid.org/0000-0003-2660-5123)
- Maud M.A. Bouwman (ORCID: https://orcid.org/0000-0002-9481-0332)
Institutions
- WinnMed (US)
- Amsterdam Neuroscience (NL)
- Mayo Clinic in Florida (US)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087358
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00