Spatial proteome profiling for distinguishing tangle‐bearing neurons and their microenvironments from healthy neurons in Alzheimer’s disease brains
This study identifies alternative markers, particularly phospho-tau epitopes S214, S396, S404, and other proteins including P62, Neprilysin, and Ubiquitin for tangle-bearing neurons. These markers are promising to improve AD diagnosis and fill gaps in knowledge regarding molecular pathogenesis of NFTs, paving the way for possibly earlier and more accurate detection and intervention strategies.
Authors
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Miranda E. Orr (ORCID: https://orcid.org/0000-0002-0418-2724)
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Shiva Kazempour Dehkordi (ORCID: https://orcid.org/0000-0003-0349-4360)
- Timothy C. Orr
- Virginia Chih-Yi Sun (ORCID: https://orcid.org/0000-0003-3129-4235)
- Hannah R. Hudson
- Ryan H Bodamer
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of Washington (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089552
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00