Behavioral and metabolic profiles in an aged, humanized <i>APP/APOE</i> mouse model of Alzheimer’s Disease risk

Metabolically, female mice had lower FBG and higher FKB relative to males. The sex difference was greater in APP/APOE4 females, which had the lowest FBG and highest FKB. The hAPOE4-driven reduction in body weight, especially in adipose tissue, further indicates a metabolic consequence in mice expressing the AD risk gene. Collectively, this program of research contributes to the determination of the translational validity of the humanized APOE and APP mouse model for preclinical target identification and therapeutic development for AD.