Harnessing the Potential of Human iPSC‐derived Microglia‐like Cells as Antigen Presenting Cells for MAIT Cells to Study AD Pathology
These experiments will allow us to apply our human iPSC-based model to studying human microglia as APC and pave the way for a broader understanding of the contributions of the MR1/MAIT cell axis in AD. To our knowledge, our proposed study will be the first of its kind to utilize iMG as APC for human MAIT cells.
Authors
- Reham Afify
- Randy R. Brutkiewicz (ORCID: https://orcid.org/0000-0002-7396-480X)
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087699
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00