Alzheimer’s disease genetic risk factors’ influence on tau onset age
Our preliminary results support a key role for CR1 in the age when tau pathology becomes abnormal in AD. The tested variant, rs1408077, is in high linkage disequilibrium with a missense variant, rs2296160, and was previously associated with CR1 expression in the temporal cortex. This adds to previous studies that reported an interaction between CR1 and APOE-ε4 associated with episodic memory decline. Future work will include genome-wide analyses of biomarker timing and multi-trait analyses.
Authors
- Megan Zuelsdorff (ORCID: https://orcid.org/0000-0002-9632-475X)
- Margo B. Heston (ORCID: https://orcid.org/0000-0002-0980-2275)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Jacob Morse
- Richard J. Chappell (ORCID: https://orcid.org/0000-0002-3891-0881)
- Yazan Hammad (ORCID: https://orcid.org/0000-0002-0394-5654)
- Yuetiva Deming
- Elena Ruiz De Chavez
- Rebecca E. Langhough
- Jordan P Teague
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086038
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00