RARE‐LacZ Mice as a Model to Study of Retinoic Acid Signaling in Alzheimer’s Disease
RARE-LacZ mice appear to have behavioral and genetic characteristics appropriate for testing VA-mediated interventions in AD models. RA signaling is prominent in mature DG cells associated with successful reversal learning. Although reversal of AD-related learning deficits by VA supplementation was not observed, testing AD mice on a VA deficient (0.4 IU/g) diet is planned.
Authors
- J.H. Strickland
- Jessica Medina
- Adam Baker (ORCID: https://orcid.org/0000-0003-0791-7324)
- J. Josh Lawrence (ORCID: https://orcid.org/0000-0001-6416-984X)
- Matthew C. Hernandez (ORCID: https://orcid.org/0000-0001-8084-9685)
- Shane Smith (ORCID: https://orcid.org/0000-0002-7205-496X)
- Ashly Hindle
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092980
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00