Topographic relationship between tau and TDP‐43 in the combined Alzheimer’s disease and Limbic‐predominant Age‐related TDP‐43 Encephalopathy Neuropathologic Changes
Our large human neuropathology study supports that, in AD+LATE-NC, TDP-43 accumulation might be a downstream consequence of nTau, which fully mediated the Aβ-TDP-43 association. Both TDP-43 and nTau exacerbate cognitive decline in AD+LATE. Interventions targeting AD pathophysiology might also delay the progression of comorbid LATE-NC.
Authors
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Sonal Agrawal (ORCID: https://orcid.org/0000-0003-2375-8888)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Hyun‐Sik Yang (ORCID: https://orcid.org/0000-0002-8318-0443)
- Lei Yu (ORCID: https://orcid.org/0000-0002-8837-2022)
- Jae Won Oh (ORCID: https://orcid.org/0009-0005-7355-3970)
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090783
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00