Mechanistic links between TMEM106B and TDP‐43 dysfunction in AD‐related dementias

Our results emphasize the use of cryptic RNAs to identify cases with TDP-43 pathology, and raises the possibility that unique transcriptome signatures may further distinguish FTLD-TDP from LATE/AD and within different TDP-43 subtypes. We showed a relationship between increased TMEM106B core deposition and greater susceptibility to TDP-43 dysfunction, potentially through dysregulation of endolysosomal function.