Modeling tau aggregation through optogenetics
These data support the feasibility of generating tau aggregates with pathological features in our cellular system. This approach has the potential to enhance the screening process of possible tau aggregation modulators allowing analysis in real time of tau aggregation in a precise manner with high spatiotemporal resolution while. This model may r be amenable to drug screening.
Authors
- Liang Zou (ORCID: https://orcid.org/0000-0001-7322-5735)
- Marcos Schaan Profes (ORCID: https://orcid.org/0009-0009-4745-0977)
- Kurt Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087377
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00