The cellular prion protein mediates Tau oligomer‐induced memory impairment in mice
In contrast to our previous findings with Aβ and α-synuclein oligomers, we demonstrate that PrP<sup>C</sup> interacts with TauOs and this binding has functional consequences. This interaction might represent an interesting therapeutic target in Alzheimer's disease and other tauopathies.
Authors
- Giovanna Musco (ORCID: https://orcid.org/0000-0002-0469-2994)
- Antonio Masone (ORCID: https://orcid.org/0000-0001-8357-5931)
- Marco Gobbi (ORCID: https://orcid.org/0000-0003-1014-6225)
- Laura Colombo (ORCID: https://orcid.org/0000-0002-3243-0270)
- Roberto Chiesa (ORCID: https://orcid.org/0000-0002-3842-3733)
- Marten Beeg (ORCID: https://orcid.org/0000-0001-7201-6704)
- Claudia Balducci (ORCID: https://orcid.org/0000-0002-3870-835X)
- Milica Cerovic (ORCID: https://orcid.org/0000-0002-8417-0503)
- Luana Fioriti (ORCID: https://orcid.org/0000-0003-2429-8967)
- Chiara Zucchelli (ORCID: https://orcid.org/0000-0003-2857-7170)
- Franca Orsini (ORCID: https://orcid.org/0000-0001-7415-9936)
- Ilaria Raimondi (ORCID: https://orcid.org/0000-0002-4218-3437)
- Gianluigi Forloni (ORCID: https://orcid.org/0000-0001-5374-3914)
- Giada Lavigna (ORCID: https://orcid.org/0000-0001-9615-0166)
Institutions
- Mario Negri Institute for Pharmacological Research (IT)
- IRCCS Ospedale San Raffaele (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092149
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00