Reactive astrocytes with reduced function of glutamate transporters in the <i>App<sup>NL‐G‐F</sup></i> knock‐in mice
Our data suggest that astrocytic glutamate transporters are affected by excess Aβ42 in the brain contributing to synaptic dysfunction in the hippocampus. Thus, our data indicate that restoring astrocyte synaptic function could be a potential therapeutic strategy to treat AD.
Authors
- Per Nilsson (ORCID: https://orcid.org/0000-0001-6450-0870)
- Maria Lindskog (ORCID: https://orcid.org/0000-0002-4178-2825)
- Luis Enrique Arroyo‐García (ORCID: https://orcid.org/0000-0002-9206-0179)
- Makoto Shimozawa (ORCID: https://orcid.org/0000-0001-9618-0533)
- Toshio KAYA
- André Fisahn (ORCID: https://orcid.org/0000-0003-1480-175X)
- Ipsit Srivastava
- Laura Álvarez-Jiménez (ORCID: https://orcid.org/0000-0003-4286-8230)
- Raúl Loera‐Valencia (ORCID: https://orcid.org/0000-0001-9376-0049)
- Silvia Maioli (ORCID: https://orcid.org/0000-0002-9577-0803)
- Montse Iglesias
- Julen Goikolea
- Maria Latorre Leal
Institutions
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085633
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00