DNA methylation associates with regional tau pathology beyond age and APOE
DNAm provides an additional mechanism to account for variance in NFTs amongst aging individuals. However, frontal cortex DNAm is more associated with frontal cortex NFTs than hippocampal NFTs. This finding suggests that region-specific DNAm may support drivers of p-tau spread between regions. Future research is necessary to determine whether DNAm differences across AD are causal or consequential.
Authors
- Anil R. Wadhwani (ORCID: https://orcid.org/0000-0002-7007-2371)
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Eddie B Lee
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Philip L. De Jager
- David A. Bennett
- David Goldberg
Institutions
- Rush University Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Columbia University Irving Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092539
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00