Enhancing Single‐Domain Antibody‐Based Protein Degradation for Synucleinopathies

2D8-PEG4-T enhances α-synuclein proteasomal degradation while maintaining 2D8's lysosomal clearance. Its superior α-synuclein clearance, compared to unmodified 2D8 sdAb in vitro and in vivo, highlights its therapeutic potential for synucleinopathies. Small sdAbs with improved brain entry and potency may enhance clinical benefits in antibody-based therapies.

Authors

Yixiang Jiang (ORCID: https://orcid.org/0000-0001-5690-2116)

Institutions

New York University (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2024-12-01
DOI: https://doi.org/10.1002/alz.090359
Primary Topic: Protein Degradation and Inhibitors
Type: article
Field-Weighted Citation Impact: 0.00

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article

Enhancing Single‐Domain Antibody‐Based Protein Degradation for Synucleinopathies

Yixiang Jiang

Dec 1, 2024

Alzheimer s & Dementia

Protein Degradation and Inhibitors

article

Enhancing Single‐Domain Antibody‐Based Protein Degradation for Synucleinopathies

Yixiang Jiang

December 1, 2024article en

Abstract

Alzheimer s & DementiaVol. 20(S1)

New York University (US)

Openalex Percentile: Top 78%

Protein Degradation and Inhibitors

DOI Open Access PDF OpenAlex

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Enhancing Single‐Domain Antibody‐Based Protein Degradation for Synucleinopathies — Yixiang Jiang · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS