Role of TDP‐43 in dysregulation of cholesterol metabolism and implications for AD

TARDBP plays an important role in the regulation of cholesterol metabolism, specifically cholesterol uptake. The presence of TDP-43 inclusions in AD may thus contribute to AD pathology through loss of function of TARDBP, causing defects in cholesterol homeostasis which lead to altered microglia function. This also has implications in better understanding Limbic-predominant age-related TDP-43 encephalopathy (LATE), a recently characterized type of dementia associated with TDP-43 proteinopathy.