Interaction between polymorphisms in <i>MBP</i> and <i>EIF2B5</i> genes is significantly associated with Alzheimer’s disease
The results of this study support the hypothesis that the interaction between MBP and EIF2B5 variants is significantly associated with AD. Our finding implies that regulation of translation and axon demyelination jointly contribute to AD.
Authors
- Svetlana Ukraintseva (ORCID: https://orcid.org/0000-0002-0079-5494)
- Rachel Holmes
- Hongzhe Duan
- Konstantin G. Arbeev (ORCID: https://orcid.org/0000-0002-4195-7832)
- Olivia Bagley
- Anatoliy I. Yashin (ORCID: https://orcid.org/0000-0003-4262-8894)
- Deqing Wu (ORCID: https://orcid.org/0000-0003-3047-7996)
Institutions
- Social Science Research Council (US)
- Duke University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093410
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00