Kv1.3 regulation of brain immune function <i>in vitro</i> and <i>in vivo</i>
We identified novel N and C-terminal domain-specific and context-dependent interactors of Kv1.3 channels in immune cells. While the N-terminus regulates protein processing and localization, the C-terminus regulates immune signaling during LPS-stimulation. Some interactions are dependent on the PDZ-binding domain. KO of Kv1.3 impacts microglial signatures under neuroinflammatory states. microglial transcripts. Identifying microglial Kv1.3 influence in AD may provide knowledge on future biomarkers and treatments.
Authors
- Hai M. Nguyen (ORCID: https://orcid.org/0000-0002-1422-7041)
- Claudia Espinosa‐García (ORCID: https://orcid.org/0000-0002-9909-9092)
- Srikant Rangaraju (ORCID: https://orcid.org/0000-0003-2765-1500)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Heike Wulff (ORCID: https://orcid.org/0000-0003-4437-5763)
- Prateek Kumar (ORCID: https://orcid.org/0000-0001-5875-4065)
- Aditya Natu (ORCID: https://orcid.org/0000-0002-3399-5513)
- Christine A Bowen (ORCID: https://orcid.org/0000-0002-2981-8629)
- Pritha Bagchi
- Hailian Xiao (ORCID: https://orcid.org/0000-0002-3796-4693)
- Young Lin
Institutions
- Emory University (US)
- Yale University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093042
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00