Neuroinflammation and synapse loss determines the cognitive fate in Alzheimer Disease
These findings suggest that enhanced tau pathology in neurites and synapses may instigate glial inflammatory responses and synapse elimination, determining the cognitive fate of individuals who harbor ADNC.
Authors
- Christine Klein (ORCID: https://orcid.org/0000-0003-2102-3431)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Ana C. Amaral (ORCID: https://orcid.org/0000-0002-7316-3295)
- Teresa Gómez‐Isla (ORCID: https://orcid.org/0000-0002-7977-2075)
- Cinthya Agüero (ORCID: https://orcid.org/0000-0001-9483-429X)
- Margaret Scapellato
- Sunny Kumar (ORCID: https://orcid.org/0000-0002-6217-2348)
- R.B. Sinha
Institutions
- Harvard University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089168
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00