Whole Genome Sequencing Analysis of Cognitively Wellderly Individuals Identifies Potential Protective Genetic Variants for Alzheimer’s Disease
Although only variants in the APOE locus have a reduced likelihood of Wellderly status in the single variant analysis, our aggregated tests suggest genes aside from APOE that are associated with Wellderly status with biological plausibility. We are pursuing replication using the Alzheimer's disease Sequencing Project (ADSP) WGS data.
Authors
- Bruce M. Psaty (ORCID: https://orcid.org/0000-0002-7278-2190)
- Anita L. DeStefano (ORCID: https://orcid.org/0000-0002-9335-2819)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Dongyu Wang
- Gina M. Peloso (ORCID: https://orcid.org/0000-0002-5355-8636)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Eric Boerwinkle (ORCID: https://orcid.org/0000-0001-8813-0544)
- Josée Dupuis (ORCID: https://orcid.org/0000-0003-2871-3603)
- Joshua C. Bis (ORCID: https://orcid.org/0000-0002-3409-1110)
- Morgan A Rosser
- Thomas H. Mosley (ORCID: https://orcid.org/0000-0003-3343-1352)
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Yanbing Wang (ORCID: https://orcid.org/0000-0002-9064-8104)
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Sabrina Abbruzzese
Institutions
- Boston University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- National Heart, Lung, and Blood Institute (US)
- Framingham Heart Study (US)
- Brown Foundation (US)
- McGill University (CA)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088478
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00