Genetic Deletion of the Presinilin‐Like Peptidase SPPL2B Significantly Reduces Neuroinflammation and Halts Production and Plaque Deposition in Pre‐Clinical Models of Alzheimer’s Disease

The results outlined in this study support a relevant connection between SPPL2b and the development of Aβ pathology in AD. In a global scenario characterized by the need to identify novel strategies to prevent and counteract AD progression, this study highlights and strengthens the importance of SPPL2b as a novel therapeutic approach for AD.