Specific expression of APOE in astrocytes reduces Aβ accumulation and plaque‐related pathology in a mouse model of amyloidosis
Together, our study reveals an important role of astrocytic APOE on the deposition and accumulation of Aβ plaques as well as on Aβ-associated downstream effects.
Authors
- Long‐Jun Wu (ORCID: https://orcid.org/0000-0001-8019-3380)
- Fangfang Qi
- Sydney V. Doss (ORCID: https://orcid.org/0000-0002-3427-4654)
- Guojun Bu (ORCID: https://orcid.org/0000-0003-3491-1016)
- Chia‐Chen Liu (ORCID: https://orcid.org/0000-0001-7203-3926)
- Yuzhou Chang (ORCID: https://orcid.org/0000-0003-4893-1886)
- Na Wang (ORCID: https://orcid.org/0000-0002-4578-4609)
- Yingxue Ren (ORCID: https://orcid.org/0000-0003-4529-5722)
- William Tauer
Institutions
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090129
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00