Neuroimmune regulation of Alzheimer’s pathology by age‐related blood‐borne factors
Together our results highlight mechanisms by which both youth-associated and age-associated blood-borne factors regulate AD pathology. Factors in the systemic environment appear to interact with microglia, cells that are intimately involved in modulation of canonical AD pathology.
Authors
- Joseph M. Castellano (ORCID: https://orcid.org/0000-0002-8026-6292)
- Ana Catarina Ferreira (ORCID: https://orcid.org/0000-0003-3723-2086)
- B Hemmer (ORCID: https://orcid.org/0000-0003-0898-5142)
- Alejandro Grau‐Perales (ORCID: https://orcid.org/0000-0002-0850-4313)
- Ralphyn Pallikunnath
- Jacob L. Rosenstadt
Institutions
- Allen Institute for Brain Science (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.083657
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00