Molecular insights into the heterogeneity of depression in Alzheimer’s disease: A single‐cell transcriptomic analysis

The results demonstrated numerous depression-associated cell-type specific DEGs in AD brains. Our single-cell analysis provides mechanistic insight into the risk to develop comorbid depression in AD and advances our understanding of shared molecular etiologies and dysregulated pathways between AD and MDD. This knowledge has a translational impact toward the identification of actionable targets as novel therapies to treat depression earlier in disease stages as a means to delay or alleviate depression onset in AD.