Association of mitochondrial DNA variants with Alzheimer’s disease phenotypes in 500K participants with whole genome sequencing from the UK Biobank
Our preliminary analysis of the 500K WGS data from the UK Biobank suggested associations between multiple mtDNA variants and AD phenotypes. Robust aggregation tests suited for rare variants are underway to assess the vast majority of the mtDNA variants (rarer) identified by WGS. Inclusion of diverse samples is warranted to reveal ancestry-specific effect of mtDNA variation on AD.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Chunyu Liu (ORCID: https://orcid.org/0000-0002-9160-0153)
- Biqi Cui
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Mohsen Sharifi Tabar
Institutions
- Boston University (US)
- Central South University (CN)
- The University of Texas at San Antonio Health Science Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090861
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.47