Large‐scale discovery of novel shared genetic etiology between stroke and neurodegenerative diseases like Dementia, Multiple sclerosis, Parkinson’s Disease, Amyotrophic Lateral Sclerosis

This is first study which shows extensive pleiotropy present between stroke and neurodegenerative diseases at genome-wide level. We found GRS of stroke subtypes for South Asian samples also associated with neurodegenerative diseases which suggest that applicability of GIGASTROKE GWAS data of Indians in prediction of neurodegenerative diseases; despite smaller sample size compared to other ancestries in world. These research findings have strong implication for future development of early diagnosis, prevention and treatment strategies for both cerebrovascular and neurodegenerative diseases.