African origin haplotype protective for AD in <i>APOEe4</i> carriers: exploring potential mechanisms
We have identified an AF-specific haplotype protective against AD risk conferred by APOE ε4. Considering the distance from APOE and the complexity of the highly SD region where the variant is located, we have identified the minimum shared haplotype from AFR origin and are investigating the potential effects of SVs and differential CpG sites. Ongoing analyses include 3D chromatin structure and LRS at higher coverage to assemble and resolve the complex genomic context of the allele.
Authors
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Marina Lipkin Vasquez
- Regina Vontell (ORCID: https://orcid.org/0000-0002-2664-8265)
- Luciana Bertholim Nasciben (ORCID: https://orcid.org/0009-0002-1518-1409)
- David A. Davis (ORCID: https://orcid.org/0000-0002-9323-6180)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Margaret A Pericak‐Vance
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091487
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00