Preliminary Insights from a Multi‐Ancestry TWAS in Alzheimer’s Disease in African and European Populations
The multi-ancestry TWAS identified 276 genes potentially associated with AD, particularly in pathways related to the disease. These findings may enhance our understanding of AD genetic risk. The limited sample size in African-descent AD GWAS may explain the lack of significant gene identification beyond the APOE locus. Future studies with more diverse populations are essential for discovering novel AD-related genes in underrepresented groups.
Authors
- Penelope Benchek (ORCID: https://orcid.org/0000-0002-7385-087X)
- Jennifer E Below (ORCID: https://orcid.org/0000-0002-1346-1872)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Xinyu Sun (ORCID: https://orcid.org/0000-0002-7394-2301)
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092593
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55