Single cell nuclei transcriptomics of human brains identify a role for homeostatic microglia in cellular senescence in Alzheimer’s disease
This work implicates the sustained activation of homeostatic microglia as an underlying mechanism of cellular senescence in the AD brain.
Authors
- Stan G. Louie (ORCID: https://orcid.org/0000-0001-5941-6690)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Bilal E. Kerman (ORCID: https://orcid.org/0000-0003-1106-3288)
- Brandon Ebright (ORCID: https://orcid.org/0000-0002-8939-6069)
- Hussein N. Yassine (ORCID: https://orcid.org/0000-0002-2483-649X)
- Marlon Vincent V. Duro (ORCID: https://orcid.org/0000-0003-2590-2900)
- Isaac Asante (ORCID: https://orcid.org/0000-0002-9628-3425)
- Shaowei Wang (ORCID: https://orcid.org/0000-0002-1267-9554)
- Boyang Li (ORCID: https://orcid.org/0000-0003-2808-9986)
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- LAC+USC Medical Center (US)
- Keck Hospital of USC (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087171
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00