Unveiling Proteomic Signatures of Tau Pathogenesis through Label‐Free Mass Spectrometry Analysis
Our study reveals numerous proteins exhibiting a significant association with tau pathology. These results align well with published findings that suggest the involvement of alternative splicing in reprogramming gene expression in the pathogenesis of AD. Further validation will be needed to assess their potential as therapeutic targets and/or diagnostic/prognostic biomarkers for AD pathologies.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- William R. Paljug
- Anuradha Sehrawat (ORCID: https://orcid.org/0000-0002-7243-5447)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Eric E. Abrahamson (ORCID: https://orcid.org/0000-0003-1787-7581)
- Yijun Chen (ORCID: https://orcid.org/0009-0001-4579-4057)
Institutions
- University of Pittsburgh (US)
- VA Pittsburgh Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092740
- Citations
- 1
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.24