Targeting cannabinoid type 2 receptors alters human tau levels in ex vivo brain slice cultures
These results suggest that CB2 alters the function of immune cells to reduce tau species in a stimulation dependent-manner. Future studies will evaluate microglia-restricted CB2 knock-out brain slices to advance our understanding of the role of brain CB2 in the microglial contribution to pathologic tau removal and potentially highlight CB2 as a therapeutic target against tauopathies.
Authors
- Malu Gámez Tansey (ORCID: https://orcid.org/0000-0002-1719-4708)
- Cecilia J. Hillard (ORCID: https://orcid.org/0000-0002-9678-748X)
- Valerie Joers (ORCID: https://orcid.org/0000-0001-6743-6587)
- Ila Bagheri (ORCID: https://orcid.org/0009-0009-0624-4536)
- Jazmyn Coronado
Institutions
- Medical College of Wisconsin (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093442
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00