DAP12 deficiency increases resilience to tau toxicity by modulating oligodendrocyte state and myelination in tauopathy mice despite elevated tau inclusions

Our findings reveal a critical role of microglial DAP12 signaling in mediating tau toxicity, enhancing our understanding of the intricate interactions among neurons, microglia, and oligodendrocytes in AD and tauopathy. Future studies will delve into dissecting the specific ligands and receptors mediating microglial interactions with other cell types.