Studying Alzheimer’s‐Related Neuronal Dysfunction Using a New Tool: Characterizing a Neurodegenerative Animal Model with Increased Neuronal‐specific miR34

The inducible global miR-34a overexpression mouse model exhibited modest dementia-like characteristics and warrants further characterization. Further interrogation of contributions from other neural or peripheral cell types in the AD phenotype induced by global miR-34a overexpression. The cell-specific nature of our model provides valuable insights into miR-34a's role in AD pathology. These findings contribute to understanding the complex, polygenomic mechanisms underlying neurodegeneration in AD and may reveal novel miR-focused therapeutic targets.